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Since PD patients are frequently on multiple therapies, it will be important for future studies to determine the independent effect of these therapies on the gut microbiome and their potential roles in the progression and management of the disease
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Strengths and Limitations This study has numerous strengths to highlight
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A recent review of the literature also showed that prolonged water fasting lowers HbA1c and insulin resistance in normoglycemic patients, but not in those with diabetes [7]
These numbers had never been observed with a pharmacological agent outside bariatric surgery making tirzepatide a genuine milestone in metabolic medicine
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