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In this post, well break down BAC, how its measured, and the factors that influence it

Cecal samples were collected at euthanization, then flash-frozen and stored at 80 C

Using the clinical trial escalation protocol (2mg starting dose with 2mg increases every 4 weeks), reaching the 12mg maintenance dose takes approximately 20 weeks

By blocking the nuclear translocation of NF-B, KPV suppresses the transcription of numerous pro-inflammatory genes

Phase 2 Side-Effect Frequencies at 4.5 mg/week (Lancet 2021) Side Effect Nausea Incidence at 4.5 mg/week 47% Side Effect Injection-site reactions Incidence at 4.5 mg/week 43% Side Effect Constipation Incidence at 4.5 mg/week 21% Side Effect Fatigue Incidence at 4.5 mg/week 20% Side Effect Allergic reactions (any) Incidence at 4.5 mg/week 10% Side Effect Vomiting Incidence at 4.5 mg/week 8% Side Effect Loose stools Incidence at 4.5 mg/week 7% Side Effect Headache Incidence at 4.5 mg/week 7% Side Effect Indigestion Incidence at 4.5 mg/week 4% Incidence was lower at lower doses

Collagen levels naturally decline in the mid-20s