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Medically reviewed by Missy Zammichieli, DNP, APRN, FNP-BC Updated March 26, 2026 HEAD-TO-HEAD HOW THEY WORK (AND WHY IT MATTERS) Both medications mimic gut hormones that your body produces naturally after eating

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JAMA 318 (14), 13671376

One of the first things that really stood out, and something many people including myself are interested in, is how Retatrutide helps with reducing appetite

While Semaglutide has been shown to be beneficial for many people with type 2 diabetes, it can also have some potential side effects