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AT A GLANCE Originally FDA-approved for type 2 diabetes, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) also lead to sustained weight loss and have revolutionized diabetes and obesity management

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*JAMA*, 300(18), 2123-2133

In addition, hirudins potent anticoagulant activity may pose a bleeding risk in the treatment of DKD, and the therapeutic window needs to be strictly defined in clinical studies

Patients without diabetes actually experienced more weight loss than diabetics in early trials, challenging earlier assumptions and suggesting broader applications for these drugs in various therapeutic approaches

The ratio is set once, under controlled conditions, rather than re-established by the end user before every dose