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Intramuscular (IM) injections are placed directly into muscle tissue, which has a richer blood supply
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However, given the cardiac and renal benefits as well as the weight loss effect of GLP-1RA, the increased PRR does not mean that clinicians should restrict the use of GLP-1RA but should remain appropriate vigilance for potential adverse effects
Off-label use for fatty liver disease specifically would be at the discretion of specialist hepatologists or endocrinologists, typically in research settings or exceptional clinical circumstances
The trial also reported dose-dependent increases in heart rate that peaked at 24 weeks and declined thereafter