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B12 deficiency produces a recognizable cluster of symptoms: fatigue, weakness, neurological changes including tingling or numbness in the extremities, cognitive fog, and in more severe cases, megaloblastic anemia
PI3K/Akt signaling promotes survival and protein synthesis
Rho small GTPase family (rac1, cdc42, and rhoA) has an established role in mediating neurite growth and spine morphogenesis (Tashiro et al., 2000
One study reported that ALS patients had signs of intestinal inflammation and dysbiosis with a shift toward microbes that can induce oxidative stress and reduce gut barrier function [214]
placebo when combined with a moderate-intensity lifestyle intervention (Supplementary Table 1)
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