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GL, RR and PR directed the experimental studies, supervised the analysis of the results and interpreted the findings in their respective laboratories

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The risk of an UTI was found to be slightly higher in group receiving sequential combination therapy (relative risk [RR] 0.96, 95% confidence interval [CI] 0.521.78) than in simultaneous combination group (RR 0.67, 95% CI 0.281.60) [57]

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