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A physician may need to evaluate persistent vomiting, severe abdominal pain, signs of dehydration, worsening reflux, gallbladder symptoms, low blood sugar risk in patients using diabetes medications, kidney function concerns, unintentional under-eating, rapid weakness or muscle loss, and medication interactions

Whichever you choose, make sure it fits your body, your goals, and your long-term health

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Some studies suggest GLP-1 medications may improve testosterone levels, potentially benefiting sexual health, while a 2025 analysis of US Food and Drug Administration data identified 185 reports of sexual dysfunction, particularly among men taking GLP-1 receptor agonists

6870 However, in patients with cirrhotic conditions (fibrosis stage 4), there is no difference in MASH regression compared to placebo treatment after SEMA 2.4 mg weekly