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The reward and intake changes some people notice are covered in GLP-1 and alcohol

Tolerability Issues Another reason could be tolerability issues

Khemis et al., 2007

& Coates, P

That works at first, but as titration schedules, missed doses, injection-site changes, and notes about side effects pile up, the process becomes messy: missed steps slow down tolerance, inconsistent injection sites can cause irritation, and symptom patterns get lost in notes or memory
Understandably, an anesthesiologist providing general anesthesia will have a different protocol than a dentist providing conscious sedation

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