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Going forwards, it will be crucial to evaluate animal and clinical datasets for signs of ADE, and to balance ADE-related safety risks against intervention efficacy if clinical ADE is observed

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Bning Journal: Molecular therapy : the journal of the American Society of Gene Therapy Journal ranking: Q1 Key takeaways: Tropism-modified AAV vectors with novel receptors significantly improve cutaneous gene therapy by increasing cell entry efficiency and targeting v8 integrin, overcoming safety concerns.