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40 Grattagliano I, Lauterburg BH, Portincasa P, Caruso ML, Vendemiale G, Valentini AM, Palmieri VO, Palasciano G

The LEADER trial demonstrated cardiovascular benefit comparable to what semaglutide would later show in SUSTAIN-6, though with a somewhat smaller magnitude of effect

A mechanism of action describes how a medication works in the body to produce its effects

Second, a decrement in serum TH was observed in the current experiment

That also means the product hasn't gone through the FDA drug approval process - supplements in this category are typically regulated under DSHEA, which requires safety but doesn't require pre-market proof of efficacy for specific medical conditions

PMID: 17015261