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Consistently feeling sad, empty, and hopeless Markedly diminished interest in pleasurable activities Significant weight loss or weight gain Increased or decreased appetite Insomnia or hypersomnia Fatigue or loss of energy Feeling of worthlessness, feeling excessive, or inappropriate guilt Diminished ability to think or concentrate, or indecisiveness Recurrent thoughts of death and suicidal ideation without a specific plan Psychomotor agitation or retardation These symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning

That process is reconstitution

Goldstein, D

Vitamin B12 deficiency

Hyperglycemia reduces instantaneous calcium intake, and increases NADPH production, thus inhibiting AMPK