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GLP-1 receptors are expressed in cardiovascular tissues, which may contribute to cardiovascular effects, though it should be noted that while some selective GLP-1 receptor agonists have demonstrated cardiovascular benefits in outcome trials, definitive cardiovascular outcome data for tirzepatide are still awaited
[1] [2] According to the UK Summary of Product Characteristics (SmPC), itching can occur primarily in two contexts : as part of injection site reactions (reported as common, affecting up to 1 in 10 people) or as a manifestation of hypersensitivity reactions
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PubMed Pi-Sunyer X, et al
Is nausea a sign that the medication is working
