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It is generally accepted that the production of oxidants has to be strictly regulated, and that the ability of cells and organisms to adequately respond to oxidative stress is one of the main regulators of aging and lifespan [111]

This review describes the available FDA approved AD drugs, examples of drugs that have recently failed in clinical trials, and tentative reasons for these failures

Cryo-EM maps have been deposited in the Electron Microscopy Data Bank (EMDB) under the accession codes EMDB-48699 (composite map) and EMDB-48638 (local refinement map)

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