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Some of the GLP-1s approved to treat T2D, such as Ozempic, are also widely known to be used for weight loss
The dose starts low and increases over time so the body can adjust to the medication and reduce the likelihood of digestive side effects
Key Phase 3 trials include: TRIUMPH-1: Retatrutide for obesity without type 2 diabetes TRIUMPH-2: Retatrutide for type 2 diabetes TRIUMPH-3: Retatrutide for obesity with type 2 diabetes TRIUMPH-4: Retatrutide for metabolic dysfunction-associated steatohepatitis (MASH) Results from these trials are expected between 2025 and 2027
These aren't magic solutions, but they're evidence-based strategies that support your body's natural systems
However, the study described in the paper indicates that the combination of semaglutide with bimagrumab delivered substantial weight loss over 72 weeks with lean mass preserved
Whelton, 1981
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