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The SGLT2i treated cohort showed preservation of eGFR over a 5-year period compared with the GLP-1 RA treated cohort (+3.5 ml/min per 1.73 m 2 vs 7.2 ml/min per 1.73 m 2 , respectively), including patients with established chronic kidney disease (CKD)
The cardboard box is not just packaging
For many people, the 14-15% average weight loss with semaglutide, combined with its better tolerability profile, represents the right balance of benefit and risk
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Even if those initiatives fail, the cost of the blockbuster weight loss medications is expected to come down in the future
Killion recently reported that chronic GIP agonism desensitizes and inhibits the activity of GIPR at least in adipose tissue potentially reconciling the similar body weight directionality observed with agonists and antagonists (69)
