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Eating less can also play a role
Regulatory History significant: February 2024 Arizona Board of Pharmacy consent agreement: In a February 2024 consent agreement, the Arizona Board of Pharmacy stated that Strive began compounding injectable semaglutide in August 2021 approximately seven months before semaglutide was added to the FDAs drug shortage list
Diabetologia (2012) 55(12):326272
These earlier agents still appear on the list and remain options where cost, formulary placement, or tolerability favour them, though the trials show smaller average effects than semaglutide or tirzepatide
So the real question is whether a pill can actually pull its weight against the shot, and which of the two is worth your attention
Early data suggest yes - Retatrutide achieved roughly 68% more weight loss than Mounjaro (tirzepatide) in trials
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