Type 3 diabetes is a term used to underscore a growing body of evidence that Alzheimers involves insulin resistance in the brain, impaired glucose metabolism, mitochondrial dysfunction, chronic inflammation, and oxidative stressmuch like in type 2 diabetes
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Adv Drug Deliv Rev 61(15):14121426
Microvascular endothelial cells (CMECs) were isolated from neonatal SpragueDawley (SD) rat hearts by the enzyme dissociation to induce hypoxia/reoxygenation (H/R) injury, and GLP-1 analogue liraglutide protected cardial microvascular endothelium from H/R injury by activating PI3K/Akt/survivin pathways (68).Liraglutide-induced PI3K activation was also able to enhance keratinocyte migration and promote wound healing in mice (69)
Some individuals become less sensitive to this hormone over time, and this results in higher glucose levels and can later result in diabetes
Generally speaking, injectables/parenterals are the space that has had the strongest hold on the oral GLP-1 agonists market