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Participants on the 12 mg dose lost an average of 28.7% of their body weight

The messenger RNA expression levels of the (A) ACAT1, (B) SREBP-2, (C) HMGCR, (D) SQLE, (E) LXR, (F) CYP7A1, (G) LDLR, (H) PCSK9, (I) SR-B1, and (J) ABCA1 genes were analyzed by quantitative real-time polymerase chain reaction and normalized to that of the ACTB gene

Nature 577 , 15 (2020)

Clinical trial participants received counseling on diet and exercise throughout the study period

MOTS-c handles cellular energy regulation, metabolic flexibility, and mitochondrial signaling

Because both participants and investigators knew which treatment was being administered, the trial introduced a degree of bias that does not affect the blinded pivotal trials