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In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)
It is prescribed by the doctor for people who are suffering from weakness, fatigue, and nerve pain
In human breast cancer cells, DADS inhibited TNF--induced release of MCP-1, a chemokine that promotes tissue remodeling, angiogenesis, and metastasis (77)
Due to their numerous advantages, both vaginal inserts and suppositories have been widely prepared in pharmacies since the 18 th century to achieve both systemic and local effects
276,421 Taken together, these observations identify the important role of ERAD, through its diverse components exemplified by HRD1 here, in the control of metabolic networks, from lipid metabolism to insulin tolerance, which are implicated in a number of physiological processes, from aging to obesity
Therefore, it is desirable to fabricate a GSH biosensor which is biocompatible and can detect at least milli-molar concentrations of GSH 72
