When mitochondria cannot increase energy output efficiently, cells may depend more heavily on creatine and phosphocreatine buffering
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Furthermore, cytoplasmic condensation is associated with the accumulation of reactive metabolic by-products and lipid peroxidation, and pretreatment of cells with the antioxidant glutathione attenuates cytoplasmic condensation and cell death
Neutralizing free radicals: Glutathione helps neutralize unstable molecules called free radicals, reducing oxidative stress and preventing cellular damage (NIH)
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