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Gastrointestinal complaints were most common, including [1, 12]: Indigestion Constipation Nausea Diarrhea Abdominal pain Vomiting These outcomes were dependent on dosage and timing, likely caused by alterations in gastric motility and intestinal uptake

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Traditionally, diabetes care relied on a mix of therapeutic classes including insulins, SGLT2 inhibitors, and biguanides such as metformin

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps regulate blood sugar and appetite

Additionally, GLP-1 receptor agonists have been associated with gallbladder and biliary disease, which can cause right upper quadrant pain and jaundice

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