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However, the predominance of rodent studies raises questions about translatability to human pathophysiology and therapeutic responses

Chronic elevation of cortisol levels , as seen in Cushing's syndrome, is associated with multiple adverse effects including: Central obesity and metabolic syndrome Insulin resistance and type 2 diabetes Hypertension and cardiovascular disease Osteoporosis and increased fracture risk Mood disturbances, anxiety, and depression Impaired immune function and wound healing Psychological stress can affect cortisol patterns, though the relationship is complex and varies between individuals

Common Side Effects: Dry mouth, constipation, altered taste, difficulty sleeping, and dizziness

- Let the syringe reach room temperature

DOI: 10.1186/s12970-017-0173-z