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To generate epithelial cell-specific ClpP knockout (ClpP IEC ) mice, ClpP flox/flox mice were crossed to Cre transgenic Villin1 Cre mice (C57Bl/6N), originally provided by Klaus-Peter Janssen (Klinikum Rechts der Isar, TU Mnchen)

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Additionally, Mohiuddin et al (165) indicated that GLP-1RAs exerted neuroprotective effects through direct action on root ganglion neurons