Initially, this compound gained attention as an antifungal agent for the surface coating of electronic goods (US patent no 2,729,676)
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Once activated, these caspases cleave gasdermins to liberate the pore-forming N-terminal domains, enabling their targeting of cellular membranes to form large transmembrane pores, which disrupts cellular electrochemical gradient, and leads to water influx and cell swelling (160, 161)
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