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hold a published patent (WO/2023/180570) that covers the in vitro method for identifying anti-senescence compounds based on detecting the binding of said compound in the presence of at least one phosphorylated amino acid in the transcription activation domain (TAD) domain of mammalian protein p53

Studies show that chemotherapy drugs induce widespread cellular senescence in healthy tissues, with these treatment-induced senescent cells secreting inflammatory factors that cause persistent fatigue, organ dysfunction, and accelerated aging in cancer survivors

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Rather than using the standard 0.25 to 0.5 mg daily dose, micro-dosing protocols employ significantly smaller amounts, typically ranging from 0.1 to 0.15 mg per administration

Jarmolowska et al