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It occurs when the immune system produces antibodies that stimulate the thyroid gland to produce excessive amounts of thyroid hormones, primarily thyroxine (T4) and triiodothyronine (T3)

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Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-mg, 10-mg, 15-mg tirzepatide doses and placebo, respectively [49]