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Gregg EW, Buckley J, Ali MK, Davies J, Flood D, Mehta R, Griffiths B, Lim LL, Manne-Goehler J, Pearson-Stuttard J et al (2023) Improving health outcomes of people with diabetes: target setting for the WHO global diabetes compact

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Furthermore, the potential for dose-dependent effectsas seen with vitamin E where high doses may paradoxically impair bone formation (146, 148) - necessitates careful optimization of treatment regimens