In a clinical trial, combination therapy with liraglutide and metformin shows significantly greater weight loss and lower incidence of hypoglycaemia, as compared to combination therapy with glimepiride and metformin 12,13
The concern is valid, given that these medications directly affect pancreatic function
Sleep Med Clin 2009;4:241255
86 KornmuellerK.AmriE
Dacheux JL, Belleanne C, Jones R et al (2009) Mammalian epididymal proteome
We definitely want patients to do their part with the diet and exercise, but unfortunately, and from a practical standpoint, that itself frequently is not enough, Hong said, adding that usually by the time patients see doctors they have already failed at achieving results through those means