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Position 2 (Alpha-aminoisobutyric acid, Aib) : The substitution of the natural amino acid at position 2 with the non-natural alpha-aminoisobutyric acid (Aib) residue is a well-established strategy for conferring resistance to dipeptidyl peptidase-4 (DPP-4) cleavage
2022;145(18):e895-e1032
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The journal praised these drugs potential for lowering obesity (and its associated chronic diseases), heart attack and stroke risk, and the symptoms of heart failure
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epigenetic aging was not pre-specified
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