mechanism of action glp-1 The protective role in neuro-ophthalmology New research identifies a mechanism

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doi: 10.1016/j.gendis.2019.12.008 189 TrotterEWHaganIM

Besides improving glucose control, reducing body weight, and lowering arterial blood pressure (surrogate endpoints), the breakthroughs were the demonstration of a significant reduction in cardiovascular and renal events in patients with type 2 diabetes at high risk

Nevertheless, the kinetic data for our mutants and rate constants for ScGrx7 and PfGrx between 10 5 10 6 M 1 s 1 are too slow for a diffusion-controlled reaction and point towards important short-lived enzymesubstrate interactions and rate-limiting re-orientations of the substrate at the enzyme surface

K., Sanchez, M., Mickel, C., and Williams-Herman, D

This multi-level intervention in oxidative processes contributes to their potent protective effects in reproductive tissues