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Let the powder dissolve completely
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Details can be found at: 10.3389/fendo.2025.1663787
This is most likely attributed to the inability of the constrained 13- and 14-membered macrocycles to adopt the proper transition states required for cleavage of the N-terminal peptide bond (Figure 8)
We are excited about this analysis, these data, and all the future questions they prompt for us to explore
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