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The nitric oxide connection is relevant because improved blood flow and vascular function support nutrient delivery, exercise performance, and metabolic function

Notably, the observed variability in efficacy between agents, particularly in the early phases of treatment, emphasizes the importance of individualized therapeutic strategies, tailored to specific clinical goals, baseline metabolic profiles, and patient preferences

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The TRIUMPH-4 data showed improvements in several cardiovascular risk markers including non-HDL cholesterol, triglycerides, high-sensitivity C-reactive protein (a marker of inflammation), and systolic blood pressure

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