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In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing
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P., Sol, S., Sharpe, J
Most unmodified peptides share this limitation, which is why pharmaceutical GLP-1 receptor agonists like semaglutide required extensive chemical modification to enable oral delivery
Plasma levels drop significantly with age
Methods and Results: Fifty-one patients completed all measurements
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