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*Daily Value (DV) not established

NR4A1 is capable of directly interacting with metformin, influencing the localization of Liver Kinase B1 (LKB1), activating AMPK, and decreasing the generation of inflammatory signals and intracellular ROS

At validated doses, these receptors increase satiety and reduce food preoccupation

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Studies suggest that this combination produces greater weight reduction, improved glycemic control, and favorable body composition changes compared to monotherapy