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doi: 10.1186/s12933-019-0916-z 44 LoCWHFeiYCheungBMY

The latter hypothesis derives from observations that GIP modulates vascular tone across peripheral vascular beds by enhancing endothelial nitric-oxide synthesis through eNOS activationan effect abolished by CaMKK, PLC, or AMPK inhibitionand demonstrates anti-inflammatory actions in adipose tissue and endothelium that correlate with increased cAMP signaling in select vascular beds, though a direct cAMP-dependent mechanism underlying its anti-inflammatory effect has yet to be conclusively established 49

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This accumulated data provides substantive support for the peptides ability to improve skin quality and address laxity

Of potential significance to diabetes is that these effects in pancreatic -beta cells leads to decreased insulin secretion

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