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The upregulated Pt transporters [e.g., organic cation transporters (OCTs), multidrug and toxin extrusion proteins (MATEs), and copper transporters 1/2 (Ctr1/2)] in DGR increase the accumulation of Pt drugs in peripheral nerves as the first step to induce PIPN (Sprowl et al., 2013

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Adamson C, Kondo T, Jhund PS et al (2022) Dapagliflozin for heart failure according to body mass index: the DELIVER trial