The benefits of IM over SubQ for a long-acting peptide like LR3 are likely negligible and not worth the added complexity and potential for tissue irritation
For most people pursuing fat loss, AOD 9604 offers an excellent balance of effectiveness, safety, and simplicity
And lets be clear, programmatic deprescribing at a population level is different than intentional, individual-level deprescribing
Other risks include an increased likelihood of hypotension and syncope
With prices fluctuating wildly, coverage rules shifting daily, and a flood of new vendors entering the market, navigating GLP-1s has become a full-time job for patients
"These results are new and shed light on the reasons for high rates of early discontinuation of semaglutide for weight loss in a real-world setting," lead author Reimar W