PMID: 10828840 Published Research Highlights Foundational Pharmacology 1998 First selective GHSR-1a agonist characterization Raun, Hansen, Johansen, and colleagues at Novo Nordisk reported that ipamorelin stimulated pulsatile GH secretion in rats, pigs, and dogs with selectivity over ACTH/cortisol release not seen with GHRP-6 or GHRP-2 at equivalent GH-effective doses
We propose this is because Gdh2 is still present and has a high affinity for the enzymatic deamination of glutamate into -ketoglutarate
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Nat Rev Gastroenterol Hepatol 15 , 425439 (2018)
Eur J Pharmacol 908:174319 Jimnez-Prez M, Gonzlez-Grande R, Garca-Corts M, Andrade RJ (2020) Drug-Induced Liver Injury After Liver Transplantation
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