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This led to the US FDA approval of Ozempic to reduce cardiovascular risk in this specific patient population in 2020 In the HARMONY Outcomes trial, patients with type 2 diabetes and cardiovascular disease who took the GLP-1 medication saw a 22% reduction in major adverse cardiovascular events compared to placebo

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Lifestyle interventions are cheaper but produce substantially less weight loss on average

MT-I is identical to -MSH except that it features norleucine instead of methionine in the fourth position, and D-phenylalanine instead of L-phenylalanine in the seventh position