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That digestive barrier is the whole reason IV and injection-based glutathione became popular they bypass the gut entirely
Emanuele et al., 2021
morphine glucuronide is pcol active acyl glucuronides are reactive, binding covalently to proteins acetylaminofluorene hydoxylamine glucuronide is reactive Would one expect M6G to be absorbed orally
For a 75 to 90kg adult, that translates roughly to 190 to 900mcg daily, which brackets the 200 to 500mcg range being used in practice
They also have lower amino acid substrate level and are low in enzymes that are needed for glutathione synthesis
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