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They achieve this by regulating the differentiation of nave CD4 + T cells into specific T-helper (Th) subpopulations, such as Th1, Th2, and Th17, via the provision of co-stimulatory signals and the secretion of distinct cytokines (214, 269, 270)
Reduction of these systems is effected in a variety of ways
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PMID 2190319
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alanine, glutamate and glutamine, along with pyroglutamate and hydroxyproline, were seen to be reduced in the sea urchin gonads from the barren habitat population in this study
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