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Over the past few decades, machine learning has profoundly impacted daily life, driving innovations such as efficient web search engines, autonomous vehicles, computer vision systems, and optical character recognition technologies 40

Combined with the prediction of CELLO, WoLF PSORT, and TargetP subcellular localization servers, plant GPXs were clustered into five groups: mitochondria and chloroplast localized GPXs, cytoplasm localized GPXs, cytoplasm/extracellular/plasma membrane localized GPXs, cytoplasm/mitochondria/chloroplast localized GPXs, and cytoplasm/extracellular/nucleus localized GPXs (Supplementary Table 4)