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Efficacy of oral folinic acid supplementation in children with autism spectrum disorder: a randomized double-blind, placebo-controlled trial

Clabault et al

They will also set an upper limit on the total weekly dose (for example, some experts recommend not exceeding ~300 mg per week in subcutaneous dosing without further evaluation) to minimize any risk of adverse effects

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Oral administration results in rapid degradation by gastric acid and hepatic first-pass metabolism, rendering the compounds inactive before reaching systemic circulation

The Potential Benefits of Dietary Glutathione on Immune Function and Other Practical Implications 31