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The Gq/11 pathway activates phospholipase C (PLC), which hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into IP3 and diacylglycerol (DAG)
Wan DY, Guo Y, Cheng Y, Hu Y, Xiao S, Wang Y, et al
In: Practical Essentials of IMRT
Along these lines, insulin resistance in T2D and obesity seems connected to low-grade chronic inflammation induced by an increased release of pro-inflammatory cytokines from predominantly visceral adipose tissue and its associated immune cells, combined with a decreased release of the insulin-sensitizing hormone adiponectin
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