The side effects are almost entirely local, not systemic
North Carolina Deputy Treasurer Frank Lester gave further context of the situation to Fierce Healthcare in an email Wednesday
Do I Have to Eat Healthy and Exercise When Taking GLP-1s
The sociability and social novelty index scores span from a score of -50, indicating complete avoidance of the conspecific during phase I and complete avoidance of the new conspecific during phase II, to a score of +50, indicating complete preference for the conspecific during phase I and complete preference for the new conspecific during phase II
However, other investigations have suggested that several GLP-1RAs may cross the bloodbrain barrier via passive diffusion 251 , a GLP-1R-mediated uptake mechanism 252 or adsorption transcytosis 253 , although different compounds may present with variable degrees of brain penetrance 254
Another joke Im hearing a lot lately is that my beloved millennial generation is hitting perimenopause and we are not going down without a fight holding on to our 2000s tube-top party days come hell or high water