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Shared side effects both medications can cause: Nausea (most common, especially when starting) Vomiting Diarrhea or constipation Stomach discomfort Loss of appetite Headache Dizziness Semaglutide-specific notes: Side effects are generally mild to moderate, and they often decrease as your body adjusts over the first few weeks

Western blot and qRT-PCR were used to determine the changes in ferroptosis marker gene expression

Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials

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The ED-A domain of fibronectin and vitronectin-integrin interactions collectively enhance TGF responsiveness and reinforce a pro-fibrotic microenvironment (260)

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