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indeed, Th1 cells have pro-inflammatory effects (a CD4 + T cell subsets) as do CD8 + T cells, while Th2 cells and regulatory T cells (Tregs) have anti-inflammatory effects (152)

Each added receptor opens a new metabolic lane GIP enhances insulin sensitivity and fat-oxidation signaling, and glucagon increases hepatic energy expenditure

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At the cellular level, GLP-1RAs provide liver protection through three main pathways: reprogramming Kupffer cells to reduce inflammation, resetting metabolism via FXR/LXR-mediated lipid efflux, and directly promoting hepatocyte survival through the PI3K/Akt pathway

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