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Most of the studies occurred over 12 to 24 weeks, though, so this may not apply to long-term use

FDA materials identify compounded injectable GHK-Cu as a safety concern because of potential immunogenicity, aggregation, peptide-related impurities, and limited human safety data 8

Geroprotective and Anticarcinogenic Activity Lifetime Murine Studies Long-term studies in mice demonstrated that DSIP administration over a lifetime decreased total spontaneous tumour incidence 2.6-fold compared to untreated controls, slowed age-related switching-off of oestrous function, decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%, and increased maximum lifespan by 24.1% compared to control groups a multi-parameter geroprotective profile that is among the most striking reported for any short regulatory peptide, and that has generated sustained interest in the DSIP analogue research field

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273 Moving from an efficient to an effective fleet The future of American sea power in the Indo-Pacific depends on the Navys ability shift from a force that is efficient to one that is more effective