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In contrast, GLP-1sincluding semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro, Zepbound)represent a significant departure from previous treatment paradigms.[127] By mimicking natural satiety signals and regulating appetite through the gut-brain axis, these medications offer a new kind of intervention that can address core drivers of obesity.[128] Clinical trials have demonstrated average weight loss of 15 percent, comparable to outcomes previously only achievable through bariatric surgery.[129] This level of efficacy, combined with growing demand, marks a potential inflection point in how obesity is treated

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Ghrelin-induced adiposity is independent of orexigenic effects

doi: 10.1093/femsre/fuaf019 181 SohnJ.LiL.ZhangL.SettemR

2) oral administration of glutathione